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Nnx'lS1 Nnx1"lv CH3CCOOH + HS-CA + NAD+        YTSO Mg2+ CH3CO-SCoA + NADH + H+ +CO2 YNpvA ُNekS^/fޏc|uNTCAv-N_ PSvv YTSOSb Nnx1"lv kxxlYNpWv N"lkxx1"lv CoA-SH FAD NAD+ kxx Mg2+ , kx }&qxxTPP+ 2. ۏeQTCA gjxTbv CH3CO-SCoA + IpYNx + H2O       gjx + CoASH zLN4Yxv zLN4Yxv 2 gjx       zLN4Yx      _gjx -H2O +H2O _gjx1"lv 3 _gjx + NAD+         Ip%tsx + NADH +H+ _gjx1"lv 4 Ip%tsx         (-n bNx + CO2 (-n bNx1"lv 5 (-n bNx+NAD++CoASH        %tspCOA+CO2+NADH+H+ v|vRVP[ gTPP+ kxx HSCoA FAD NAD+ %tsxTbv 6 %tspCoA+GDP+H3PO4        %tsx+GTP+CoASH H2O Mg++ %tsx1"lv 7 %tsx+FAD       ^"}x+FADH2 ^"}xv 8 ^"}x+H2O      gx gx1"lv 9 gx + NAD+         IpYNx+NADH+H+ \~TCA Cycle 1 ;`e z_ CH3COCOOH + 4NAD+ + FAD+ + GDP + Pi + 3H2O (3CO2 + 4NADH2 + FADH2 + GTP 2 ۏLMO (W~|SOW(-NۏL0 3 (WTCA-N NRP[NnxNu N*NRP[CO2 ُ-NvN|R1S^/f|T8T\O(uʑ>eCO2egn |u-N/f NNuCO2v S gTCA-NMbNuCO20 4 (WTCA-N gN!k1"lǏ z Nu4RP[NADH2 RP[FADH2 ۏeQ|T8T HN>eQϑ HN'l~T ubH2O 5 |  ˆ}v( 8hxSNǏTCASuN" NvT| b:N iirSOQTyir(vNlSvgmb 6 ϑvNu NRP[Nnx(WTCA-NNu4RP[NADH2(12*NATP0 NRP[FADH2(2*NATP+GTP qQ15*NATP NRP[a|NuvATP 15(2+8=38*NATP0FO[ES g36*NATP V:N|u㉧NuvNADHۏeQ~|SOm2*NATP0 TCAvutaIN cON'Yϑvϑir( O iiru}T;mR /f N'YN"v-N_g b:NN*NN"x SN/f@b gir(v;N'lS_0NuvCO2 NRO g:gSOuirTb NRcQSOY0 cO g:girTbvxg0 TCAvc gjxTbv YNpCOA        gjx IpYNx ( ATP/fSgb6RBR _gjx1"lv _gjx        (n bNx ( ADPOۏvN^irNTR (-n bNx1Hv YTSO (-n bNx          %tspCOA %tspCoA0NADHb6R Nnx1"lvpyruvic acid dehydrogenase /fNYv YTSO HTWtb_ NyvvY*NNUSMO~b ؏ gmQyRVP[ (W[bNnx'lS1v~NekS^-N ؏ gNyvw\O(u0 Model of the PDHC from E. coli(4600KD)60*NY D=300A E1 Nnx1"lv 24ag WTPP 0Mg2+ USSO96KD0'lS10 E2S"lkxxlYNpv 24ag USSO70KD WkxxCOA Mg2+ lyYNpW0RCOA E3S"lkxx1"lvUSSO56KD W NAD0 FAD0 Mg2+ 'lSWkxpQu0 $NyvKinaseov Phosphatase xxov0X[(WSvxxSTSxxSv0(W~|SOؚATP/ADP ؚYNpCoA/CoA ؚNADH/NAD`Q N Kinase)R(uATPOv YTSO Nς(lxkWxxS O YTSOS Nnx'lS^Qba TCA CycleЏl_Nba0 vSCoA NAD+ AMPOxxov;mS NςaakW N4lxx SYؚCa2+ \ }_NOۏSxxS Ov YTSO;mS TCA CycleRЏl0 Te 1"lv YTSOxxSN&TvN*N͑VP[/f~|SO-NPyrSm^ S_PyrSm^ؚe SNRKQ g1uATPؚ_wvb6R O~||T8T~~ck8^ۏL0 N0xx b|_Pentose Phosphate Pathway, PPP HMP (WؚI{ iir-N ؏ gSN N~Ǐ|u ۏL g'l|T8T_ sSa|SNvc'lS1"l b:N6-xxa|x (W1vv\O(u N (WNADP+ vSN N 6-xxa|x'lS:N5-P 8hn| >eQCO2 @bNSxx b|_0 NuvNx|~N|Rlnl\O(u RP[QWVNbc ͑ec~ub N0V0N0mQ0Nx|0 ;`e z_/f C6H12O6+12NADP+(6CO2+12NADPH2_smQ!k 6 G-6-P + 12NADP+ + 7H2O( 6CO2 + 12 NADPH2 + 5 G-6-P + Pi yrp 1 N~|u a|vc1 1"l0 2 /f^'lSv RP[WVly ͑c 3 @b gvv(W~ހFm-N @bNPPP(W~ހFm-NۏL 4 a|_sN!k>eQNRP[CO2 Nu2RP[NADPH2 @bNN*Na|RP[{_^'lS~6!k_sNu6RP[CO2 12RP[NADPH20 xx b|_vutaIN 1 ُ*N_Nuv-NNir(Wut;mR-NASR;mÍ lT*NN"S^ NIQT0|T8Tޏ|0 Y5-P-8hn|T5-P-8h|/f8hxvSe 3-P-ulN|uNvl0xxg| 7-P-of)Y^n|O|T8TNIQT\O(uޏ|0 2 ~TbS^cONADPH2 yr+R/fTbNADPH2O~ NADPH iir~|SO'lSb_bATP0 3 Nbu gsQ 4-P-dӅ|T3-xxulSNTbIx [/fYywQbu\O(uT_*hHQu\O(uvYZir(vMRSO0Y(g( } I{0 T~~-NEMPNPPP_T`SkO N T (uh[-NvC6/C1egaϑ0 C6 hC6-Gʑ>ev14CO2   =             PPP-NvCO2egC1 C1 hC1-Gʑ>ev14CO2 Ype~~vkeQ'Yϑvϑ uir'lSR N T HQ uir'lS/f1 (W;m~ހQ ck8^SO)nT g4lvsX NۏLv2 S^ek[b ekʑ>eϑ3 O2 >eQCO2TH2O (W'lSN؏Sv{|vPS NۏL0 @bNb(WuirSOQ g:gir(ek'lS0ʑ>eϑvǏ zSuir'lS _NS~ހ|T8Tb~ހ'lS0 uir'lSe_ R'l 2 1"l 15uP[ ek^ir'lS1"lH N5uP[~|T8T ORP['lN OvH~Tb_bH2O0 25uP[ OThe Electron Transport Chain |T8TN"v-NNir'lS1"l 5uP[T(P[l@w(W~|SO N cN[z^cRvN~5uP[ OSO O0RRP['l ُ*NhSy|T8T0ُNHT5uP[ OSOSb "l OSO;N/fNAD FAD0\O:N1"lvvvbW0 2H 2H 2e 5uP[ OSO;N/f O5uP[v~ހr }SO|0~ހr }N_SIU:NWv~Tˆ}v SRa, b, cQ{|0 Fe3+Fe2+ 0 9hncT OSOvhQ'lS؏S5uMO NS(uyr_vb6RBRRe|T8Tb(WSOY~bNagۏL!jb5uP[ OՋ g~xvzؚI{ iir|T8TvcR 5uP[z'lS؏S5uMO(WT OSO O "lǏCoQT (P[2H+1yQeg 8ny(Wnm-N 5uP[2e~~l~ހr }b, c, a, a3z^ O g~(WCyt a3b5uP[N~'lRP[ OvQ;mS ~Tub4l @bN|T8TǏ z-Nv8T'lsS/f(WُNekۏLv0 1uNCyt a3/f(Wُ*Nuir'lSǏ zv+gzw\O(u @bNُyvSS+gz'lSvTerminal Oxidase 0 (W|T8T-NTbATP g N*NMO @bNN*NRP[NADH2~Ǐ|T8TNu N*NRP[ATP NRP[FADH2NuN*NRP[ATP0 3. 'lSxxS\O(uOxidative Phosphorylation 'lSxxS ~|T8Tv'lSǏ z/f*N>evǏ z 4O@wATPvTb b^ir'lS>eQvϑS8T6e.X[weg @bN/f'lS\O(uNxxS\O(uvPTۏL ُNǏ zy:N'lSxxS\O(u0 xxS\O(ucADP + Pi ( ATPvǏ z0 2 P/0kP:0 /f~|SO'lSxxS;mRRvN*N͑ch k8T6eN*N'lSP[@boSe:gxxRP[pevk0[(/fkmN*N'lSP[ 1uADPb_bATPvpev0(W|T8T-N NNADH_Y'lS P/0:N3NFADH_Y P/0R:N2HCNb6R~ހr }+gz'lSv P/0R:N10 3 xxS{|W IQTxxSNIQT5uP[ OvPT OADPxxSNuATPvǏ z0 'lSxxSN|T8T5uP[ OvPT OADPxxSNuATPvǏ z0 ^irxxS N~ǏIQTb|T8T |T8T\O(uR㉄v-NNirǏRP[Qϑv͑eRM v^\RϑN~ADPb_bATPvǏ z0Y1,3 Nxxulxub3 xxulxe NuN*NATPNRP[PEPlS:NNnxe_NNuN*NATP0 q_TxxSǏ zۏLvoBRYvPTBRDNP Nq_T5uP[ O FO;xNxxS0؏ g|n0[[Yb }AKCN0NaN30COI{0 4 ϑ{ NRP[a|{_^'lSubCO2TH2OSNu686CSaSϑ0 b_b38*NATPV 7.3CSaS ( 38 = 277.4CSaS 277.4 / 686 = 40% FO(W|uN-NNuvNADHۏeQ~|SO ؏mϑ (uS2*NATP @bN[ESub36*NATP0 7.3CSaS ( 36 = 262.8CSaS 262.8 / 686 = 38% N0b0l|T8TCyanide-Resistant Respiration (W[-NwS ~ހr }'lSvv\O(uSKCN NaN3 COb6R [NNFe_SIU~T4xOWv;m'` Q\'lSxxS\O(u0 FO gN iir NOea (W g0lSirX[(WvagN N N gN[v|T8T\O(u ُy|T8TSb0l|T8T0 ُag_SNuN*NATP Vdk P/Ok=1.0 FO>eQ'Yϑp0 )YWSfylD v[O0q^ S20000(l O2/gfw.hr |T8T>epO~~)n^XؚASQ0RNASQ^0pϑOT2TT%cSS_fkۏeQނ O| gN gk NpMRy/}'Yϑm| T~EMP-TCA'lSR ~|SO;m'`_ؚ0 vQ[YlÔ \S NNg[I{_N g0 mQ0~|SOY+gz'lSvTerminal Oxidase Out of Mitochondria 1. bOW@x'lSvAscorbic Acid Oxidase Ny+TCuv'lSv X[(WN~ހ(-Nb~T(W~ހX N0 bOW@x + 1/2O2 ( S"lbOW@x + H2O ,܃Tg[-NY0 2. Z'lSvPhenol Oxidase +TCuv'lSv X[(WN(SO _SOQ OZ + 1/2O2 ( + H2O lÔ9 gRS 1uNZ'lSvv\O(u OSr [_uir gk[\O(u @bNSNOb iirv$OS ُe$OS|T8TXؚ _NS$O|T8T0 6R6]N-N ZP~6HQp @gR sS@g{kZ'lSv MQNu Oc~rn0 3. Ǐ'lSirvPeroxidase Ǐ'lS"lvCatalase YNx'lSvGlycollic Oxidase 0 N0|T8T\O(uvc6RControl of Respiration 1. ]e_He^T|u㉄vPasteur Effect ]e_geSsbuk̃N g'lagNl0Re'lagNe Su\O(uXR Ne'll0R g'le Su\O(uS0Rb6R @bNb'l[Su\O(uvb6RsaS]e_He^0 @bN(We'le ~ހQۏLSu e'l|T8T 'lSm^XR e'l|T8TQ1_ g'l|T8TXR 0RgN'lSm^e Sv\O(u\Pbk ُev'lSm^Se'l|T8Tvqmpp0 e'l|T8Tk g'l|T8Tm^ir_ :NNHN ]e_He^v,g( 1 O2[~ހQATP/ADPv |u㉌T'lSxxQ[NADPv gHeSm^ gO2X[(We 'lSxxS\O(u;mÍۏL 'YϑmADP NuATP V P6Ru\O(uۏLeO2e 'lSxxSS; ǏiRvADP:Ro|uۏL0 eO2eؚSm^vADPTPicؚxxg|ovv;m'` _NOۏ|u0 2 (W|u-NNuvNADH(W gO224h4 8 < @ n p r t z |     $ ( * . 0 4 8 ( , P R <ؾ޵޵ؾخإإخhf5CJo( hfCJo(hf5CJo(h(CJH*o( h(CJH*h(CJH*o( h(CJH* jh(CJo( jmh(CJ h(CJ h(CJo(h(5CJo(h(5CJo(hf5CJo(724hb ( n D Z * , R <b@` & F ^`gd(`gd(gd($a$D 8:<&rtz|".XZ\ƺƺƱƺƺƱƒƒhf5CJOJhfCJH*OJo(hfCJH*OJo(hfCJOJo(hf5CJH*OJo(hf5CJOJo( jhf5CJOJo(hf5CJH*o( hf5CJ hfCJo(hf5CJo(8@<&\^`&&pLNf`   "6:\`bdfjlprz|&02<>pNhjﯦ hf5CJhf5CJo(hfCJH*o( hfCJo(hfCJH*OJo(hf5CJOJ jhf5CJOJo(hf5CJH*OJo(hf5CJOJo(hfCJOJo(hfCJOJ8f4Rh^&~(d$a$` "$*,>@JL\^df.Z^ 8:VBDFJLP\`vxz|꿸hfCJH*OJo(hfCJH*OJo(hfCJOJ hf5CJhf5CJOJo(hf5CJo(hf5CJOJo( jahfCJOJo(hfCJOJo( jhfCJOJo(<|~ ,. 6 8 f l !""("z"(#*#4#<#>#@#B#D#Z#n#v#x#z#|###################츯츯츯츯 jhfCJOJo(hfCJH*OJhfCJOJ hfCJo( hfCJhf5CJo(hf5CJOJo(hfCJH*OJo(hfCJOJo(hfCJH*OJo(@ `0 f l!!"#L#^##$<$$%r%t%%D&F&z&&&:'^''`#$ $$$$$$$$>%H%J%L%`%b%p%r%t%%%%F&X&v&z&&&&&&&&&&&&&&&&6':'t'v'''''''''''''(p(r(v(x((((ĻĻĻĻ hfCJo( hf5CJhfCJH*OJhf5CJo(hf5CJOJo(hfCJH*OJo(hfCJH*OJhfCJH*OJo(hfCJOJhfCJOJo(@''''((((.)n))))*T****8++++,`,b,,,,8- & F`((((2)4)Z)\))))))))))***********<+>+b+d+++0,2,Z,\,,,,,,(-\-^-r-t-----....F.H.V.X.....j/l/////żżͼ jahfCJOJo(hfCJH*OJhfCJOJhfCJH*OJo(hfCJH*OJo(hfCJOJo(hf5CJOJhf5CJOJo(E8-v---Z... /F/// 080r0t0000 1R1T1n1~11V2|2333`/////n0t000N1P1T1n11111111111122$2(262:2F2J2V222222233H3J3X3Z333&4(4*4H4J4L44ĸĬĬģĸĕĸĸĸډډ jhfCJOJo( jhf5CJOJo(hf5CJOJhf5CJH*OJo(hf5CJH*OJo(hf5CJOJo(hfCJH*OJo(hfCJH*OJo(hfCJH*OJhfCJOJhfCJOJo(533:4p4444555555"6<6^6`666666(7f777d8f88`4445555586:6666677(7*77777f88899 9p9r9v9z999999:::.:::::;;.;0;L;P;h;߳ꫢꫢꫢꐊhfCJH*o( hfCJ hfCJo(hfCJH*OJo(hfCJH*OJhfCJOJhf5CJOJ jahfCJOJo( jhfCJOJo(hfCJH*OJo(hf5CJOJo(hfCJOJo( jhfCJOJo(288$9T99999;;B<D<<x=z====4>>>> ?B????@@@`h;j;n;;;;;;;D<<"=&=^=`======== > >>>$>&>\>`>h>j>l>n>v>z>>>>>>d?f?|?~???????@@@@"B$B.B2B6B8BlBrBzB|BBBBBBB hf5CJhf5CJH*o( jhf5CJo(hf5CJH*o(hfCJH*o(hf5CJo( hfCJo(hfCJH*o( hfCJF@.ABAAAB:BBBBCCZC$DrDtDDEXEErFFFFFFFFHG & F`BBBBBBBCCCCCC6D8DDPDRDXDZDtDE"EXE:FL0>prƔȔؔڔ "$(*.0NPR jhfCJo( jahfCJo(hfCJH*o(U hfCJh(5CJo(hf5CJo( hf5CJhfCJH*o( hfCJo(FXXXYY"rҎԎ,@xrtLpB`eۏeQ~|SO5uP[ O 'lS0 (WeO2e vc؏SNnx:NYNbsNx Oۏu0NADHNAD v0 .υ4lg MNOO2Sm^ O g'l|T8TM0RgNOP^ S N:Ro|u NMQǏRm.υirbYNNu0 2N"Metabolic Control N"/f|T8T\O(uv;N_0 1 (ϑ\O(uSt SS^-N^irNNirKN c(ϑ\O(usQ|S^s^a0 2 Sg gyir(~T(Wvvg*N~gMO }l9eSvvPSR FO_N9eSNvv;m'` YxxSv e;m'`vbr`(WMO NcSN*NAMPe SuSg\O(u b:N g;m'`var` AMP/f[vSgckHe^P[ ATP(W TNMO~Te OvSSbe;m'`` @bNATP/f[vSgHe^P[0 3 PPPv NADPH / NADPzN'`b6R NADPHؚe b6RG6P1"lvv;m'`0 4 TCA gjxYe c6RxAmۏeQTCAv^ Sb6RNnxovv;m'` R:_ATPvb6RHe^ Q\gjxvTb0 3. wEnergy Charge Regulation w/f~ހ-Nؚxxr`4ls^vNyϑ^ Ǐ~ހQzxKNlS[|T8TN"v/fw0 [ATP] + 1/2[ADP] w =             [ATP] + [ADP] + [AMP] @bNR_~wegATPv/f_͑v wؚe ATPy/}Y |T8TSb6R ~ހQ~cϑvADP |T8TMbck8^ۏL0N,wOc(W0.8-0.90 ATP؏b6RNnx1"lv gjx1"lv (-n bNx1"lvI{0 CoA_N gSb6R0 \~ N0ؚI{ iir|T8T|~vY7h'`SvQutaIN 1|T8TN"_Y7h'` | EMP TCA t^{ev~~ PPP yrkS6k !kuirb_b x'lSYNx_s0 qQ T_/f|uNEMP a|(Nnx e'le Nnx ( R| + CO2 g'leۏeQTCAsNnx(YNpCoA(IpYNx (WTCA-N(CO2+H2O PPP_a|(G6P(CO2+H2O 2|T8T5uP[ O|~vY7h'`V S^uNvNADH2ۏeQ|T8T ~'lSxxSNuATP0 ;N /eЈ}v1uNNADH1"lv N T g4yb0lv|T8T5uP[ O/e0 3+gz'lSv|~vY7h'` ~ހr }'lSv YZ'lSv bOW@x'lSv YNx'lSv b0lvNbc'lSv iir NPRir vQQsXu;msXvSS NeSS utrQ_NuSۏ z SS (WgvۏS-N SU\Q|T8T|~vY7h'` /fؚ^^'`vhs (WgN iir gNeg yr[`Q N SNNag_:N;N[ TNNutR ir(N"vޏ| gN_S\O:NNyeP0 N0~ހQ[MO EMP~ހ(-N~ހV TCAs~|SOl( PPP~ހ(-N~ހFm |T8T~|SOQt] N 'lSxxS mp'l|T8T~ހ(-N~ހFm N0ϑ)R(u EMPNRP[a|(2*NNnx 2NADH2 2ATP TCANnx ( CO2 + H2O 4NADH2 1FADH2 1ATP PPPG6P ( CO2 + H2O 12NADPH2 e'l|T8Ta|(YN sNx 2ATP ,{ N q_T|T8T\O(uvV }Factors Affecting Respiration N0|T8TsRespiratory Rate h:y|T8T\O(u'Y\vch0 USMO iirPge0USMOeQ@b8T6eO2vϑb>eQCO2vϑ0 8TO2(l/KQ͑/\e >eQCO2(l/g.fw/hr USMOekmg N v8TO2ϑ T iiry{| N T R|T8T:_^ N T TN iir N ThV[ YN N Tr`b N TSeg |T8T:_^GW N T (u~Y~CO2RgN 'l5ugI{SKm_lSONbcϑ0tl|T8Tb\{P[l0 iirPge)n^0!(l O2/gfw/h'Yr^7|220.06 S'Y22108'Y9h20960-1480'YS23266\ i*h13251)YWSf^3015600-31800dw N0|T8TFUThe Respiratory Quotient ُ/f|T8T\O(uSN͑ch c iir~~(WN[eQ |T8T\O(u>eQvCO2N@b8T6eO2vKQRP[pebSOyvkeQCO2 RQ        8T6eO2 2. Q[|T8TFU1 2 'lSm^:O2eۏLe'l|T8T R|T8TFUO'Y'Ycؚ0 3 ir(l g{_^'lS RRQOQ\ 4 vQ[N"vq_T llS:N| /fNy'lS\O(u R8T'lϑXY |T8TFUQ\ YSuTb\O(u R|T8T^ir N[hQ'lS |T8TFUR'Y0 yP[ Se|T8TFUvSS leyP[dye^laEmd ~NYv'll Yd_Ǐm WXg~ )n^SNOe 8^ bpy0 yP[ Se YpeRQ = 1 m|yP[ Se RQSN1.0 ( 1.3yP[S1u0.4n NGS0 N0q_T|T8TvQV } 1. Su( T~~|T8T:_^ N T NkKQ͑@b+TvSu( gsQ N,/f+TSu(vϑؚ |T8T:_^'YY|^ZvRu~~ [+TSu( EeNkKQ͑{|T8T:_^e 8^ؚǏp~~ 0 2. ~|SO 1uNTCAsT|T8T(W~|SOQۏL ~|SO:N~ހv S5uz ~ހ-N~|SOpeϑY R|T8T:_^ؚ0 3. ATP/ADPvk

ADP 1\Ob6RATPvNu MNO|T8T SKN ATP)R(uYe Bl'YNO ROۏ|T8T0 [ATP] + 1/2 [ADP] w =         N  N,(W0.8-0.9 [ATP] + [ADP] + [AMP] 4|T8T^ir+Tϑ ~ހQ|T8T^irXR |T8Ts NGS0100KQ:x4lSTirvĞSSGr(W[)n N ʑ>eCO2:N896 mg/h Y(W|-N2)Y Km_ phV[ 0g[I{ukhV[ > SGrI{%{QhV[0kSؚ~3^4 P V0sXagN[|T8Tvq_T 1. )n^ |T8T\O(u/fN*NvOS^ N)n^sQ|_[R |T8T\O(u_N g*NgؚTgNOvP^ sSgؚpTgNOp ُ/fcO|T8TۏLvgؚTgNO)n^0 g)n^O|T8TǏ zc~0W g_0WۏLv)n^ b/fcOc|T8T:_^gYNgؚ3z[r`v)n^0 (WgNOpNgpKN |T8T\O(u)n^GSؚ XR0Ǐgp )n^GSؚ NM0 N,(W)n^XR0R10!N Ne10!-30!-N |T8T\O(uv)n^|peQ10~:N2^2.50Q10   )n^XR10! S^^XRv Ppe0 |T8T\O(uvg)n^v^ N/fg)RN iiruSv)n^ V:Nُe iirmv^irgY [ g:girvy/} N)R @bNuvg)n^N,NON|T8Tvg)n^0 2. 4lR iirSOQhV[T~~+T4lϑ[ iir|T8T:_^vq_T_N_'Y0 Y7{|\OiryP[(WΘr^r` N |T8Tg_1_ ُeyP[+T4lϑ~12%]S FOS_yP[+T4lϑǏ15%e |T8T:_^ŏcؚ 0R30-35%e |T8Tk_YXRQAS P0 [NS g[I{+T4lϑY0ck(WuvhV[ Yr^e+ |T8TS R:_ /fV:N(W~~:4le ~ހQ4lNv;mÍ m|Rb| R gYvSOvc)R(uv|T8TW(0 3. 'lRS O2/f iirۏLck8^|T8Tv͑VP[ :'lOvcq_T|T8T:_^T|T8T'`(0 'lRSNOe |T8TKNXR XR S_'lRSN[evO2SO|T8T)R(u |T8T>eQvCO2_NIQT\O(u@b TS0 4 IQT\O(ub_b g:girb:N|T8T\O(uv^ir l g|T8T\O(uOyP[b|^ׂ _N NS g gIQT\O(u0 5 IQT\O(uT|T8T\O(uvk IQT\O(u|T8T\O(uSeCO2 + H2O g:gir + O2NirCH2O + O2CO2 + H2OSuv~ހhV S~SOEMP-~ހ( TCA0|T8T(W~|SOQagNIQ NSuIQfGWSۏL~ހ+TS~ }~ހNUOu;m~ހnIQ g:girSf[vNADP+ ! NADPH2NAD+ ! NADH2xxSIQTxxS'lSxxS ^irxxSeHN" TS\O(u_S\O(u kS~SO ~|SO kIQTxxSN'lSxxS kIQ|T8TTf|T8T 2. |T8T\O(uN ˆ}v( 8hxN"vsQ| |T8T\O(uO~ ˆ}v( 8hxN"v-NNirTϑ0 1 |u㉌TPPP-N gxxulxNu 1Sxx1\/ful|T8Tv͑-NNirNnx'lS1b_bYNpCoASۏNek)Tb_bx ُNySTirQ~vPS STb0 2 |T8T-NNuvNnx (-n bNx IpYNx ^"}x ~(lWSTSlS:NN(lx 7(lx )Y蕬Q(lx SۏLˆ}v(Tb0 3 PPP-Nv8h|/f8h|8hxv;NSe @b gTbǏ z-NvϑegnN|T8T\O(u0 xxulx ! ul        Nnx ! YNpCoA ! x Nnx!N(lx (-n bNx!7(lx IpYNx!)YQ(lx 4 1uPPPSNur(lx ! IAA TCA-N)YQ(lx ! ˆ(lx ! YNp 5 PPP ! ~ހXir( N0|T8TN~ހuSRespiration and Development of Cell ~ހvS Rˆ ! 8O ! 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